intercalated disc proteins

2. -, Gustafson-Wagner EA, et al. The Xin repeat-containing proteins, mXinα and mXinβ, localize to the intercalated disc (ICD) of mouse heart and are implicated in cardiac development and function. Am. 3. Gap junctions allow ions to pass from one cardiac muscle cell to another, providing an extremely fast conduction of action potentials through cardiac muscle tissue. Thank you for subscribing! 2007;293:H2680–H2692. 2014;5:404. NF2 Activates Hippo Signaling and Promotes Ischemia/Reperfusion Injury in the Heart. -, Wang DZ, et al. As opposed to the ID, the lateral membrane (LM) of cardiomyocytes has a different makeup. R01 HL125925/HL/NHLBI NIH HHS/United States, R01 HL138757/HL/NHLBI NIH HHS/United States, R01 HL149401/HL/NHLBI NIH HHS/United States, T32 HL007572/HL/NHLBI NIH HHS/United States, Vermij SH, Abriel H, van Veen TA. 2014 Nov;13(3 Pt B):571-81. doi: 10.1016/j.scr.2014.04.010. 4. In fact, as noted in this chapter, defects in either membrane domain are now clearly implicated in aberrant vertebrate cardiovascular physiology and potentially fatal acquired and congenital human disease. Front Biosci (Landmark Ed). Fig. -. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. 5. We hate spam as much as you do. In Xinβ mutant hearts levels of phosphorylated NF2 are substantially reduced, suggesting an impairment of Hippo-YAP signaling. Intercalated discs (ICD), specific cell-to-cell contacts that connect adjacent cardiomyocytes, ensure mechanical and electrochemical coupling during contraction of the heart. The authors declare no competing interests. Three types of special structures — fascia adherens, desmosomes, and gap junctions — are found in the intercalated discs to help in the connection of the cardiac muscle cells. 1999;126:1281–1294. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Ablation of mXinα results in adult late-onset cardiac cardiomyopathy with conduction defects.  |  2016 Aug 19;119(5):596-606. doi: 10.1161/CIRCRESAHA.116.308586. 2. Matsuda T, Zhai P, Sciarretta S, Zhang Y, Jeong JI, Ikeda S, Park J, Hsu CP, Tian B, Pan D, Sadoshima J, Del Re DP. The ends of each cardiac muscle cell form intercalated discs where they meet neighboring cardiac muscle cells. Cardiovasc.  |  Here, we show that loss of Xinβ, a newly-identified component of ICDs, results in cardiomyocyte proliferation defects and cardiomyopathy. The classic definition of the ID includes three main structures: the desmosome, which functions as a cell anchor, the adherens junction (AJ), wh… Development. Finally, many gap junctions form between the cardiac muscle cells to allow material to pass between the cells. Fig. Heart-specific YAP S127A overexpression rescues…. The intercalated disc (ICD) occupies a central position in the transmission of force, electrical continuity and chemical communication between cardiomyocytes. Three types of cell junction make up an intercalated disc — fascia adherens, desmosomes and gap junctions. Loss of Xinβ results in alteration of the Hippo-YAP signaling pathway in the…, Fig. Res. Model of Xinβ regulation of the Hippo-YAP signaling pathway in cardiomyocytes. Xinβ negatively modulates Hippo-YAP signaling by recruiting phosphorylated NF2 to the sarcolemmal membrane of cardiomyocytes, leading to the reduction of total NF2 protein, repression of Hippo signaling, and the activation of the downstream mediator YAP (left panel). Role of the intercalated disc in cardiac propagation and arrhythmogenesis. Xinβ interacts with NF2 to modulate the Hippo-YAP signaling in the heart. Each gap junction is made of connexin proteins that form a tunnel through the cell membranes of the cardiac muscle cells, allowing small molecules, including ions, to pass through. Our study reveals a molecular mechanism by which cardiac-expressed intercalated disc protein Xinβ modulates Hippo-YAP signaling to control heart development and cardiac function in a tissue specific manner. Epub 2016 Jul 11. NLM Zou J, Ma W, Li J, Littlejohn R, Zhou H, Kim IM, Fulton DJR, Chen W, Weintraub NL, Zhou J, Su H. Proc Natl Acad Sci U S A. Each intercalated disc contains many finger-like extensions of plasma membrane that interlock with identical structures on the neighboring cell. Abnormal localization of intercalated disc proteins including the desmosomal protein plakoglobin (γ-catenin), the gap junction protein connexin 43 (Cx43), and the sodium channel protein Nav1.5 has been observed in patients with ACM and in experimental disease models (4–8). Fig. Hippo Deficiency Leads to Cardiac Dysfunction Accompanied by Cardiomyocyte Dedifferentiation During Pressure Overload. Innerbody Research does not provide medical advice, diagnosis, or treatment. The mXinα directly interacts with β-catenin, p120-catenin and actin filaments. (adsbygoogle = window.adsbygoogle || []).push({}); Innerbody Research is the largest home health and wellness guide online, helping over one million visitors each month learn about health products and services. J. Physiol. -, Wang Q, et al. It hosts, among others, costamers and focal adhesions, linking sarcomeres to the extracellular matrix (ECM).2 Although the ID and LM have several proteins in common, such as vinculin and α-actinin, and ion channels,3,4discussing the LM exceeds the scope of this review. NIH COVID-19 is an emerging, rapidly evolving situation. Get the latest public health information from CDC: https://www.coronavirus.gov. HHS Three types of special structures — fascia adherens, desmosomes, and gap junctions — are found in the intercalated discs to help in the connection of the cardiac muscle cells. Physiol. Our mission is to provide objective, science-based advice to help you make more informed choices. Requirement of a novel gene, Xin, in cardiac morphogenesis. Decreased cardiomyocyte proliferation in Xinβ…. Fig. Please try again. Wang Q, Lin JL, Wu KH, Wang DZ, Reiter RS, Sinn HW, Lin CI, Lin CJ. 3. See this image and copyright information in PMC. Desmosomes help to bind cardiac muscle cells together, but form smaller, tighter junctions compared to the fascia adherens. There was an error submitting your subscription. Xin proteins and intercalated disc maturation, signaling and diseases. Please enable it to take advantage of the complete set of features! Now please check your email to confirm your subscription. Harnessing Hippo in the heart: Hippo/Yap signaling and applications to heart regeneration and rejuvenation. Ikeda S, Mizushima W, Sciarretta S, Abdellatif M, Zhai P, Mukai R, Fefelova N, Oka SI, Nakamura M, Del Re DP, Farrance I, Park JY, Tian B, Xie LH, Kumar M, Hsu CP, Sadayappan S, Shimokawa H, Lim DS, Sadoshima J. Circ Res. The net result of the strong connections and fast ion conduction is the contraction of cardiac muscle tissue like a single functional unit. The increased surface area of the finger-like extensions of cell membrane provides ample room for these connections to form. The fascia adherens are bands of proteins that connect the actin filaments of the sarcomeres in each cardiac muscle fiber to the sarcomere in the neighboring cells, producing a single unified chain of sarcomeres. Decreased cardiomyocyte proliferation in Xinβ KO hearts. Circ Res. Intercalated discs are unique structural formations found between the myocardial cells of the heart. Epub 2014 May 6. USA.gov. Intercalated discs play a vital role in holding cardiac muscle cells together using the fascia adherens and desmosomes. -, Kleber AG, Saffitz JE. Front. Heart Circ. Consequently, this pathway may represent a therapeutic target for the treatment of cardiovascular diseases. This site needs JavaScript to work properly.  |  Unsubscribe at any time. Neddylation mediates ventricular chamber maturation through repression of Hippo signaling. The fascia adherens are bands of proteins that connect the actin filaments of the sarcomeres in each cardiac muscle fiber to the sarcomere in the neighboring cells, producing a single unified chain of sarcomeres.

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